Abstract
Human CD8+ TEMRA cells in neurodegeneration: Foes and friends
References
Hamann D, Baars PA, Rep MH, Hooibrink B, Kerkhof-Garde SR, Klein MR, et al. Phenotypic and functional separation of memory and effector human CD8+ T cells. The Journal of experimental medicine. 1997;186(9):1407-1418.
Muroyama Y, Wherry EJ. Memory T-cell heterogeneity and terminology. Cold Spring Harbor Perspectives in Biology. 2021;13(10):a037929.
Arosa FA, Esgalhado AJ, Padrão CA, Cardoso EM. Divide, conquer, and sense: CD8+ CD28− T cells in perspective. Frontiers in Immunology. 2017;7:665.
Correia MP, Costa AV, Uhrberg M, Cardoso EM, Arosa FA. IL-15 induces CD8+ T cells to acquire functional NK receptors capable of modulating cytotoxicity and cytokine secretion. Immunobiology. 2011;216(5):604-612.
Li Y, Xiao J, Li C, Yang M. Memory inflation: Beyond the acute phase of viral infection. Cell Proliferation. 2024;57(12):e13705.
Sun Q, Dong C. Regulators of CD8+ T cell exhaustion. Nature Reviews Immunology. 2025:1-23.
Wu H, Prados MC, Vaeth M. Metabolic regulation of T cell exhaustion. Immune Discovery. 2025;1(1):10005.
Esgalhado AJ, Reste-Ferreira D, Albino SE, Sousa A, Amaral AP, Martinho A, et al. CD45RA, CD8β, and IFNγ Are Potential Immune Biomarkers of Human Cognitive Function. Frontiers in Immunology. 2020;11:592656.
Esgalhado AJ, Reste-Ferreira D, Weinhold S, Uhrberg M, Cardoso EM, Arosa FA. In vitro IL-15-activated human naïve CD8+ T cells down-modulate the CD8β chain and become CD8αα T cells. Frontiers in Immunology. 2024;15:1252439.
Cardoso EM, Lourenço‐Gomes V, Esgalhado AJ, Reste‐Ferreira D, Oliveira N, Amaral AS, et al. HLA‐A23/HLA‐A24 serotypes and dementia interaction in the elderly: Association with increased soluble HLA class I molecules in plasma. HLA. 2023;102(6):660-670.
Anderson KM, Augusto DG, Dandekar R, Shams H, Zhao C, Yusufali T, et al. Killer cell immunoglobulin-like receptor variants are associated with protection from symptoms associated with more severe course in Parkinson disease. The Journal of Immunology. 2020;205(5):1323-1330.
Zhang N, Bevan MJ. CD8+ T cells: foot soldiers of the immune system. Immunity. 2011;35(2):161-168.
Zhang Z, Duan Z, Cui Y. CD8+ T cells in brain injury and neurodegeneration. Frontiers in Cellular Neuroscience. 2023;17:1281763.
Hu D, Weiner HL. Unraveling the dual nature of brain CD8+ T cells in Alzheimer’s disease. Molecular Neurodegeneration. 2024;19(1):16.
Latour YL, McGavern DB. Beneficial role of GZMK+CD8+ T cells in neuro degeneration. Nature Immunology. 2025;26:1002-1003.
Delacher M, Schmidleithner L, Simon M, Stüve P, Sanderink L, Hotz-Wagenblatt A, et al. The effector program of human CD8 T cells supports tissue remodeling. Journal of Experimental Medicine. 2024;221(2):e20230488.
Singh SK, Krukowski K, Laumet GO, Weis D, Alexander JF, Heijnen CJ, et al. CD8+ T cell–derived IL-13 increases macrophage IL-10 to resolve neuropathic pain. JCI insight. 2022;7(5):e154194.
Arosa FA. On the Origin and Function of Human NK-like CD8+ T Cells: Charting New Territories: Frontiers Media SA; 2018.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2025 Fernando A. Arosa, Elsa M. Cardoso (Author)